Experimental epilepsy

Lukasiuk K, Pirttila TJ, Pitkänen A. Upregulation of cystatin C expression in the rat hippocampus during epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy. Epilepsia 43(Suppl 5):137-45, 2002

Nissinen J, Large C, Startton S, Pitkänen A. Effect of lamotrigine treatment on epileptogenesis: An experimental study in rat. Epilepsy Res 58:119-32, 2004

Nissinen J, Lukasiuk K, Pitkänen A. Is mossy fiber sprouting present at the time of the first spontaneous seizuresin rat experimental temporal lobe epilepsy? Hippocampus 11:299-310, 2001

Pitkänen A. New pharmacotherapy for epilepsy. Drugs 7:471-477, 2004

Pitkänen A, Kubova H. Antiepileptic drugs and neuroprotection. Expert Opinion in Experimental Therapy 5(4):777-798, 2004

Pitkänen A, Nissinen J, Nairismagi J, Lukasiuk K, Grohn OH, Miettinen R, Kauppinen R. Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy. Prog Brain Res 135:67-83, 2002

Histology

Miettinen R, Kalesnykas G, Koivisto E. Estimation of the total number of cholinergic neurons containing estrogen receptor-alpha in the rat basal forebrain. J Histochem Cytochem 50:891-902, 2002

Mikkonen M, Alafuzoff I, Tapiola T, Soininen H, Miettinen R. Subfield- and layer-specific changes in parvalbumin, calretinin and calbindin-D28k immunoreactivity in the entorhinal cortex in Alzheimer's disease. Neuroscience 92:515-532, 1999

Riedel A, Miettinen R, Stieler J, Mikkonen M, Alafuzoff I, Soininen H, Arendt T. Reelin- immunoreactive Cajal-Retzius cells: The entorhinal cortex in normal aging and Alzheimer's disease. Acta Neuropathologica (Berl). 106:291-302, 2003

Dementia

Gureviciene I, Ikonen S, Gurevicius K, Sarkaki A, van Groen T, Pussinen R, Ylinen A, Tanila H. Normal induction but accelerated decay of LTP in APP + PS1 transgenic mice. Neurobiol Dis 15:188-95, 2004

Gureviciene I, Puoliväli J, Pussinen R, Wang J, Tanila H, Ylinen A. Estrogen treatment alleviates NMDA-antagonist induced hippocampal LTP blockade and cognitive deficits in ovariectomized mice. Neurobiol Learn Mem 79:72-80, 2003

Heikkinen T, Kalesnykas G, Rissanen A, Tapiola T, Iivonen S, Wang J, Chaudhuri J, Tanila H, Miettinen R, Puolivali J. Estrogen treatment improves spatial learning in APP + PS1 mice but does not affect beta amyloid accumulation and plaque formation. Exp Neurol 187:105-17, 2004

Kumlin T, Iivonen H, Miettinen P, Juvonen A, van Groen T, Puranen L, Pitkäaho R, Juutilainen J, Tanila H. Mobile phone radiation and the developing brain: behavioral and morphological effects in juvenile rats. Radiat Res 168:471-9, 2007

Liu L, Ikonen S, Tapiola T, Tanila H, van Groen T. Fimbria-fornix lesion does not affect APP levels and amyloid deposition in the hippocampus of APP+PS1 double transgenic mice. Exp Neurol 177:565-574, 2002

Minkeviciene R, Banerjee P, Tanila H. Memantine improves spatial learning in a transgenic mouse model of Alzheimer's disease. J Pharmacol Exp Ther 311:677-82, 2004

Oksman M, Iivonen H, Hogyes E, Amtul Z, Penke B, Leenders I, Broersen L, Lütjohann D, Hartmann T, Tanila H. Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice. Neurobiol Dis 23(3):563-72, 2006

Wilson IA, Ikonen S, Gureviciene I, McMahan RW, Gallagher M, Eichenbaum H, Tanila H. Cognitive aging and the hippocampus: How old rats represent new environments. J Neurosci 24:3870-8, 2004

Stroke and brain ischemia

Barbelivien A, Jolkkonen J, Rutkauskaite E, Sirviö J, Sivenius J. Differentially altered cerebral metabolism in ischemic rats by alpha2-adrenoceptor blockade and its relation to improved limb- placing reactions. Neuropharmacology 42:117-126, 2002

Clarke J, Thornell A, Corbett D, Soininen H, Hiltunen M, Jolkkonen J. Overexpression of APP provides neuroprotection in the absence of functional benefit following middle cerebral artery occlusion in rats. Eur J Neurosci 26:1845-52, 2007

van Groen T, Puurunen K, Mäki H-M, Sivenius J, Jolkkonen J. Transfomation of diffuse beta-amyloid precursor protein and beta-amyloid deposits to plaques in the thalamus following transient occlusion of the middle cerebral artery in rats. Stroke 36:1551-1556, 2005

Jolkkonen J, Palomero Gallagher N, Zilles K, Sivenius J. Behavioral deficits and recovery following focal cerebral ischemia in rats: glutamate and GABA receptor binding. Behav Brain Res 138:187-200, 2003

Karhunen H, Virtanen T, Schallert T, Sivenius J, Jolkkonen J. Forelimb use after focal cerebral ischemia in rats treated with an a2-adrenoceptor antagonist. Pharmacol Biochem Behav 74:663-669, 2003

Mäkinen S, Kekarainen T, Nystedt J, Liimatainen T, Huhtala T, Närvänen A, Laine J, Jolkkonen J. Human umbilical cord blood cells do not improve sensorimotor or cognitive outcome following transient middle cerebral artery occlusion in rats. Brain Res 1123:207-15, 2006

Zhao C-S, Puurunen K, Schallert T, Sivenius J, Jolkkonen J. Effect of cholinergic medication, before and after focal photothrombotic ischemic cortical injury, on histological and functional outcome in aged and young adult rats. Behav Brain Res 156:85-94, 2005

Special techniques

Lappalainen R, Narkilahti S, Huhtala T, Liimatainen T, Suuronen T, Närvänen A, Suuronen R, Hovatta O, Jolkkonen J. SPECT imaging shows accumulation of stem cells into internal organs after systemic administration in middle cerebral artery occlusion in rats. Neurosci Lett 440:246-50, 2008

Jolkkonen J, Jokivarsi K, Laitinen K, Gröhn O. Subacute hemorrhage and resolution of edema in Rose Bengal stroke model in rats coincides with improved sensorimotor functions. Neurosci Lett 428:99-102, 2007

Ihalainen JA and Tanila H. In vivo regulation of dopamine and noradrenaline release by alpha2A-adrenoceptors in the mouse nucleus accumbens. J Neurochem (in press). Ihalainen JA, Tanila H. In vivo regulation of dopamine and noradrenaline release by ? 2A- adrenoceptors in the mouse prefrontal cortex. Eur J Neurosci 15:1-7, 2002

Puurunen K, Jolkkonen J, Sirviö J, Haapalinna A, Sivenius J. Selegiline combined with enriched- environment housing attenuates spatial learning deficits following focal cerebral ischemia in rats. Exp Neurol 167:348-355, 2001